Research Article

Expression of -Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients

Table 2

MGMT content in bladder tumours and uninvolved tissues measured by quantitative immunofluorescence.

VariableUninvolved tissueTumour tissueDifference tumour uninvolved š‘ƒ

% positive nuclei 4 2 . 8 Ā± 1 3 . 5 5 7 . 3 Ā± 2 0 . 3 1 4 . 5 Ā± 2 0 . 5 .002
Mean fluorescence 1 2 6 . 0 Ā± 2 3 . 5 108.5Ā±24.9 āˆ’ 1 7 . 5 Ā± 2 7 . 1 .004
Integrated fluorescence 1 . 9 Ā± 1 . 4 5 . 5 Ā± 3 . 7 3 . 6 Ā± 3 . 5 < .001