Site-Selective Artificial Ribonucleases: Oligonucleotide Conjugates Containing Multiple Imidazole Residues in the Catalytic Domain

<table>Kinetics of tRNA 
								Phe cleavage by the conjugates: (a) tRNA cleavage by B-Im(4/1) (3) (rhombs), B-Im(4/2a) (4a) (squares), B-Im(4/3) (5), (asterisks), B-Im(8/4+1) (10) (triangles), and B-Im(24/4+2) (12) (crosses) under standard conditions at conjugates concentration 10 μM. (b) tRNA cleavage by B-Im(4/1) (3) at concentrations ranging from 0.5 to 50 μM.</table>

Journal of Nucleic Acids

fig3

Figure 3

Figure 3: Site-Selective Artificial Ribonucleases: Oligonucleotide Conjugates Containing Multiple Imidazole Residues in the Catalytic Domain 