The Effects of Molecular Crowding on the Structure and Stability of G-Quadruplexes with an Abasic Site

Figure 5

Plots of the molecular crowding effects on enthalpy change for G-quadruplex formation {Δ𝐻^∘_{(40wt%PEG200)}−Δ𝐻^∘_(0wt%PEG200)} versus abasic site effects on enthalpy change for G-quadruplex formation {Δ𝐻^∘_(AP−𝑋)−Δ𝐻^∘_(AP−0) at 0 wt% PEG200 (𝑋 indicates the numbers from 1 to 11)} in a buffer of 100 mM NaCl, 50 mM Tris-HCl (pH 7.0), and 1 mM Na₂EDTA at 0 wt% (0 mol L⁻¹) and 40 wt% (2 mol L⁻¹) PEG200.