Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA
Figure 1
RPA domain structure, constructs used in these studies and their corresponding crystal structures. RPA-AB contains RPA1181-441. RPA-CDE includes RPA1382-616 and intact RPA2 and RPA3. RPA-CDE-core consists of RPA1438-616, RPA243-171, and intact RPA3. RPA-DE includes RPA243-171 and intact RPA3. RPA-C is composed of RPA1432-595 with 7 point mutations (V435T, W442Q, V465T, V469T, F523S, F567S, and I571T). Crystal structure representations of RPA-AB apo, RPA-AB + dC8, RPA-CDE-core, and RPA-DE are shown next to their domain maps [6–9].
