Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA
Figure 3
CD characterization of the Gq23 and TC23 oligonucleotides. (a) Antiparallel model of Gq23 (G black, T red, and A green). Note, the third G-quartet stack (from the top) contains an A instead of the canonical G. Pink circles indicate sodium ions that aid in G-quartet formation and stacking. This hypothetical model shows just one of several possible base pairing arrangements for a Gq23 intramolecular quadruplex. (b) Spectra of Gq23 recorded in a 1 cm cuvette at 25°C in 100 mM NaCl (black), 10 mM NaCl (red), and the TC23 sequence in 100 mM NaCl (dashed blue).
