Review Article
Unwinding and Rewinding: Double Faces of Helicase?
Table 1
Human helicases containing annealing activity.
| | Helicases | Unwinding activity
(Polarity) | ATP requirement for annealing activity | Other activities | References |
| | RNA helicase II (Gu, DDX21) | | − | | [40] | | p68 family (p72, Ddx42p) | | + (Ddx42p);
− (p68, p72) | | [41, 42] | | RNA helicase A (DHX9) | (3′-5′) | + | | [44] | | RECQ1 | (3′-5′) | − | | [49, 50] | | WRN | (3′-5′) | − | 3′ to 5′ exonuclease | [51, 52] | | BLM | (3′-5′) | − | | [51, 53] | | RECQ4 | (3′-5′) | − | | [54] | | RECQ5β | (3′-5′) | − | | [55] | | Pif1 | (5′-3′) | − | | [56] | | Dna2 | (5′-3′) | − | 5′ to 3′ endonuclease; 3′ to 5′ exonuclease | [57] | | CSB | | − | | [58] | | HARP (SMARCAL1) | | + | | [11–14] | | AH2 | | + | | [15] | | TWINKLE | (5′-3′) | − | | [59] |
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Note: “+” stands for ATP is required; “−” for ATP not required.
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