Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The Pd2+ Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside
Figure 4
CD spectra of the duplexes formed between the modified (7X) or unmodified (7A) oligonucleotide and complementary DNA oligonucleotides having thymidine (10T) or 2′-deoxycytidine (10C) opposite to the artificial monomer (or adenosine) in the presence and absence of Pd2+; [oligonucleotides] = 3.0 μM, [K2PdCl4] = 0/3.0 μM, I(NaClO4) = 0.1 mol L−1, pH = 7.4. (a) 7X:10T, (b) 7X:10T + Pd2+, (c) 7X:10C, (d) 7X:10C + Pd2+, (e) 7A:10T, (f) 7A:10T + Pd2+.