Journal of Nucleic Acids / 2012 / Article / Sch 1

Research Article

Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The Pd2+ Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside

Scheme 1

Preparation of the phosphoramidite building block 2. Reagents and conditions: (a) H2NNH2 â‹… H2O; (b) acetylacetone, THF, TFA; (c) DMTrCl, pyridine; (d) TBDMSCl, imidazole, DMF; (e) 2-cyanoethyl-N, N-diisopropylchlorophosphoramidite, triethylamine, CH2Cl2.

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