Chemical Approaches for Structure and Function of RNA in Postgenomic Era

Table 12

Tgs1 interacting proteins [70–72]. The Tgs1 (trimethylguanosine synthase 1) interacting proteins are listed. It is interacting with proteins involved in many aspects of RNA metabolism such as transcription, spliceosome assembly, maturation, and modification.

Tgs interacting proteins [70]
Transcription apparatus (regulators of RNA polymerase II transcription); (1) Rpn4 (TF; Proteasome subunits and U2 snRNA gene); (2) Spt3 (SAGA complex); (3) Srb2 (mediator complex); (4) Soh1 (Med31; mediator complex); (5) Swr1 (ATPase; binds to 5′ end of yeast transcription units); (6) Htz1(H2AZ) (binds to 5′ end of yeast transcription units); (7) CBP (binds to human PIMT/Tgs1); (8) P300 (binds to PIMT/Tgs1); (9) PBP (binds to PIMT/Tgs1); (10) PRIP (binds to PIMT/Tgs1; [71])	Spliceosome assembly; (1) Mud1 (yeast homolog of U1A); (2) Mud2 (yeast homolog of U2AF65); (3) Nam8 (Mud15) (homolog of TIA-1); (4) Brr1 (snRNP); (5)Lea1 (U2A; U2snRNP); (6) Ist3 (Snu17; U2 snRNP); (7) Isy1 (Ntc30; interacts with Prp19); (8) Cwc21 (component of Cef1 complex); (9) Bud13 (Cwc26) (Cef1 complex); (10) SMN (HeLa cell) [72]
RNA end processing and decay; (1) Trf4 (Pap2; catalytic subunit of TRAMP); (2) Lsm1 (decapping complex); (3) Pat1 (decapping complex)	RNA modifying factors; (1) SmB (snRNP; interacts with YNL187/Swt21); (2) SmDL (snRNP); (3) Cbf5 (snoRNP); (4) Nop58 (snoRNP); (5) Mrm (RNA 2′-O-methyltransferase)