Journal of Nucleic Acids / 2012 / Article / Fig 2

Research Article

Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1

Figure 2

Bioinformatics analysis and annotation of predicted target genes recognized by the upregulated ncRNAs in the cortex and cerebellum of SCA1 subjects and old healthy individuals. (a) Gene set enrichment analysis and functional annotation of ncRNA target genes with significant enrichment score in the cerebellum of an SCA1 patient. (b) Gene set enrichment analysis and functional annotation of ncRNA target genes with a significant enrichment score in the frontal cortex of an SCA1 patient. (c) Gene set enrichment analysis and functional annotation of ncRNA target genes with significant enrichment score in the cerebellum of an aged healthy individual. (d) Gene set enrichment analysis and functional annotation of ncRNA target genes with significant enrichment score in the frontal cortex of an aged healthy individual. (e) Ubl ubiquitination pathway genes with significant enrichment for ncRNA response elements in the cerebellum of SCA1 patient. (f) Ubl ubiquitination pathway genes with significant enrichment for ncRNA response elements in the frontal cortex of SCA1 patient.
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