Superior Silencing by 2′,4′-BNA^NC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

Figure 4

Relationship between target affinity and antisense potency. IC₅₀ as a function of 𝑇_𝑚 values of 2′,4′-BNA^NC-based AONs (solid line) and 2′,4′-BNA/LNA-based AONs (dotted line).