Potential of Peptides as Inhibitors and Mimotopes: Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries

Table 1

Summary of the selection of CMPs with lectins.

Target lectins (abbreviations)	Peptide library	Peptide motif or representative sequences (peptide name)	Lectin-binding carbohydrate structures	References	Notes*
Concanavalin A (ConA)	X8, X6	YPY motif	Man; Glc	[13, 25, 26]	Inhibition of Man binding
Griffonia simplicifolia I-B4 isolectin (GS-I-B4)	X6	SSLRGF	Gal𝛼1-3Gal	[27]	Inhibition of RBC agglutination
Bandeiraea simplicifolia I-B4 isolectin (BS-I-B4)	XCX15	NCVSPYWCEPLAPSARA	Gal𝛼1-3Gal	[28]	Inhibition of RBC agglutination
E-selectin	X12	DITWDQLWDLMK	Sialyl Lewis^X [Neu5Ac𝛼2-3Gal𝛽1-4(Fuc𝛼1–3)GlcNAc]	[29]	Inhibition of cell adhesion, reduction of neutrophil rolling, and so forth
	X7	IELLQAR		[30]	Octameric MAP, inhibition of HL-60, and B16 cell adhesion
Concanavalin A (ConA); Lens culinaris agglutinin (LCA); Pisum sativum agglutinin (PSA)	X12, CX7C	CNTPLTSRC; CSRILTAAC	Man; Glc	[31]	Inhibition of Man binding; docking study
Lectin from Helix pomatia (HPA)	X12	VQATQSNQHTPRGGGS	O-linked 𝛼-GalNAc; Galβ1-3GalNAc; 𝛼-GlcNAc	[32]	Tetrameric dendrimer, stimulation of IL-8, and IL-21 secretion
Lipopolysaccharide (LPS) binding protein (LBP); CD14	X12	FHRWPTWPLPSP (MP12)	Lipopolysaccharide	[33]	Inhibition of LPS-induced INF-𝛼 expression
Influenza virus hemagglutinin (HA)	X15	ARLPRTMVHPKPAQP (s2); ARLPR [s2(1–5)]	Neu5Ac𝛼2-3Gal	[17]	N-stearoyl peptide; inhibition of flu infection

* RBC: red blood cell; IL: interleukin; INF: interferon.