Potential of Peptides as Inhibitors and Mimotopes: Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries

Table 2

Summary of the selection of CMPs with oligosaccharide-binding antibodies.

Target antibodies; (abbreviations)	Name of antibody	Peptide library	Peptide motif or representative sequences (peptide name)	Carbohydrate antigen	References	Notes*
Anti-Lewis^Y (Le^Y)	B3	X8	APWLYGPA	Fuc𝛼1-2Gal𝛽1-4(Fuc𝛼1-3)GlcNAc	[34, 35]	Induction of anti-Le^Y immune responses
	BR55-2; 15-6A	X15	WRY-containing peptide		[36]	Cross-reaction with anti-Le^X
Anti-sialyl Lewis^X (sLe^X)	FH-6	X15	WRY-containing peptide	Neu5Ac𝛼2-3Gal𝛽1-4(Fuc𝛼1-3)GlcNAc	[36]	Cross-reaction with anti-Le^Y; octameric MAP-QS21
Anti-Lewis^X (Le^X)	L5	X12, CX7C	CSRLNYLHC	Gal𝛽1-4(Fuc𝛼1-3)GlcNAc	[37]	Inhibition of CD24-induced neurite outgrowth
Antilipooligosaccharide (LOS)	—	X7	SMYGSYN, APARQLP	LOS of group B Neisseria meningitidis	[38]	Peptide-DT
Antilipooligosaccharide (LOS)	—	X12	NMMRFTSQPPNN and so forth	LOS of nontypeable Haemophilus influenzae	[39]	Peptide-KLH
Anti-𝛽-1,2-oligomannoside	DJ2.8	X7	FHENWPS	𝛽-1,2-oligomannoside	[40]	Peptide-KLH
Anti-L2/HNK-1	L2-412	X15	FLHTRLFVSDWYHTP, FLHTRLFV	SO4-3GlcA𝛽1-3Gal𝛽1-4GlcNAc	[41]	Promotion of neurite outgrowth
Anti-Gal	B	X7, CX7C	FHENWPS, FHEFWPT	Xenoreactive 𝛼-Gal antigenic epitope	[42]	Inhibition of RBC agglutination
Anti-GMDP	E6/1.2	X15	RVPPRYHAKISPMVN	N-acetylglucosaminyl-𝛽1,4-N-acetylmuramyl-alanyl-D-isoglutamine (GMDP)	[43]	Peptide-OVA
Antiglucitollysine	41; 226	X12, CX9C	CTSRXC motif	Glc-Lys	[44]	Inhibition of Glu-Lys binding
Antihigh-mannose oligosaccharides	2G12	X15CX	ACPPSHVLDMRSGTCLAAEGK (2G12.1)	Man9GlcNAc2 (HIV-1 gp120)	[45]	X-ray analysis (no structural mimic)

* DT: diphtheria toxoid; KLH: keyhole limpet hemocyanin; OVA: ovalbumin.