Research Article
Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population
Table 4
Influence of various covariates and genotypes on dermatological adversities among exposed group compared with asymptomatic control group.
| | Characters | Category | Exposed SYMP | Control ASYMP | OR (95% CI) | | () (%) | () (%) |
| | Sex | Males | 20 (52.6) | 65 (43.9) | 1 | | Females | 18 (47.4) | 83 (56.1) | 0.71 (0.345–1.441) |
| | Age (years) | ≤35 | 20 (52.6) | 69 (46.6) | 1 | | >35 | 18 (47.4) | 79 (53.4) | 0.67 (0.408–1.109) |
| | Smoking | Never | 30 (79) | 135 (91.2) | 1 | | Current/past | 8 (21) | 13 (8.8) | 2.77 (1.055–7.272)* |
| | GSTT1 | Wild | 27 (71) | 127 (85.8) | 1 | | Null | 11 (29) | 21 (14.2) | 2.46 (1.064–5.705)* | | | | 2.53 (0.946–6.77)# |
| | GSTM1 | Wild | 24 (63.2) | 92 (62.2) | 1 | | Null | 14 (36.8) | 56 (37.8) | 0.96 (0.458–2.005) |
| | NQO1 | Wild (C/C) | 16 (44.4) | 72 (48.65) | 1 | | Mutant (C/T + T/T) | 20 (55.6) | 76 (51.35) | 1.18 (0.569–2.463) |
| | hOGG1 | Wild (C/C) | 13 (34.2) | 54 (36.5) | 1 | | Mutant (C/G + G/G) | 25 (65.8) | 94 (63.5) | 0.905 (0.428–1.915) |
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SYMP: symptomatic, ASYMP: asymptomatic, OR: odds ratio, CI: confidence interval; #odds ratio adjusted for smoking; *.
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