Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA
(a) Sequences of PAA “hits” from the initial screen and their corresponding dissociation constants for the bulge region of TAR. (b) Binding curve for SFF as determined by quantifying changes in cleavage at U23 as a function of SFF concentration (c) Structure of TAR RNA hairpin.
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