Population-Sequencing as a Biomarker of Burkholderia mallei and Burkholderia pseudomallei Evolution through Microbial Forensic Analysis
Figure 2
Accumulated genomic diversity expected from different passaging approaches. (a) Imposing a single cell genetic bottleneck at each passage step causes a gradual mutational shift with all descendent cells being closely related to one another. (b) By passaging a random subset of microbes at each step, accumulated mutational diversity within the lineage population is expected to be much greater.
