Thermodynamic and Structural Analysis of DNA Damage Architectures Related to Replication

Figure 1

Hydrogen atom abstraction at a 2′-deoxyribose moiety in DNA replication relevant architectures. (a) Model replication substrates: duplex (a1) and flap (a2). (b) 2′-Deoxyribose radical intermediates in duplex (b1) and flap substrates (b2). (c) Strand-break products resulting from oxidative sugar damage in duplex (c1) and flap substrates (c2).