Research Article
Thermodynamic and Structural Analysis of DNA Damage Architectures Related to Replication
Table 1
Comparison of
values for unmodified and
3 containing DNA architectures relevant to replication. The position of
3 is indicated by “Z”.
| | ID | Base Sequence | (°C) | (°C) |
| | 1 | | | | | | | | 5′-OvHg | | | | | | 1A | X = OH | Y = TTTTTT | 51.6 ± 0.3 | — | | 1B | X = OH | Y = ZTTTTT | 51.6 ± 0.1 | 0 | | dsDNA | | | | | | 1C | X = AAAAAA | Y = TTTTTT | 57.9 ± 0.1 | — | | 1D | X = AAAAAA | Y = ZTTTTT | 52.8 ± 0.1 | −5.1 | | Fork | | | | | | 1E | X = GACTGT | Y = TTTTTT | 47.3 ± 0.3 | — | | 1F | X = GACTGT | Y = ZTTTTT | 47.3 ± 0.2 | 0 |
| | 2 | | | | | | | | 3′-OvHg | | | | | | 2A | X = TTTTTT | Y = OH | 51.6 ± 0.3 | — | | 2B | X = ZTTTTT | Y = OH | 50.2 ± 0.3 | −1.4 | | dsDNA | | | | | | 2C | X = TTTTTT | Y = AAAAAA | 58.9 ± 0.1 | — | | 2D | X = ZTTTTT | Y = AAAAAA | 53.6 ± 0.2 | −5.3 | | Fork | | | | | | 2E | X = TTTTTT | Y = GACTGT | 48.6 ± 0.2 | — | | 2F | X = ZTTTTT | Y = GACTGT | 47.9 ± 0.2 | −0.7 |
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