miRNA Influences in NRF2 Pathway Interactions within Cancer Models

Figure 3

Overview of carcinogenesis and NRF2 responses. Tumour progression is recognized to induce dysregulated miRNA expression, resulting in exacerbated NRF2 activity. Such downstream effects include reduced apoptotic mechanism induction and exacerbation of chemoresistance properties by the tumour, therefore thwarting any conventional cancer therapeutic success.