In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

<div>Structures of the locked nucleoside 2′-O-4′-C-methylene-guanosine (LNA), where B stands for a nucleobase (<b>1</b>); the unlocked nucleoside 2′-3′-acyclic-ribonucleotide (UNA) (<b>2</b>); 4-thio-unlocked-uridine (<b>3</b>); 2′-C-piperazino-unlocked-uridine (<b>4</b>); an acyclic thymine derivative, (S)-GNA-T (<b>5</b>); and the beta- and alpha-thymidines (<b>6</b>).</div>

Journal of Nucleic Acids

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Figure 10

Figure 10: In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids? 