In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

Figure 12

2′-Deoxydinucleotides connected by the natural phosphodiester (P-O) (1); the thiophosphoryl or phosphorothioate (P-S) (2) and the nonionic methylphosphonate (P-Me) linkages (3); the 1,4-disubstituted dihydroxyanthraquinone linker (4); the acyclic (R)-4-aminobutane-1,3-diol phosphodiester backbone (5); and the pyrene molecule used for loop (6).