Figure 1: The specificity of oxazole yellow dye YOYO-1 towards DNA. The dye YOYO-1 (at concentration of 10 nM) very specifically binds to or interchelated DNA molecules (mDNA, 1 μM DNA-ph concentration) and increases fluorescence by many folds. YOYO does not bind or increase its fluorescence intensity in the presence of prion protein (α-PrP, 2 μM).