A Sequence-Dependent DNA Condensation Induced by Prion Protein

<div>The specificity of oxazole yellow dye YOYO-1 towards DNA. The dye YOYO-1 (at concentration of 10 nM) very specifically binds to or interchelated DNA molecules (mDNA, 1 <i>μ</i>M DNA-ph concentration) and increases fluorescence by many folds. YOYO does not bind or increase its fluorescence intensity in the presence of prion protein (<i>α</i>-PrP, 2 <i>μ</i>M).</div>

Journal of Nucleic Acids

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Figure 1

Figure 1: A Sequence-Dependent DNA Condensation Induced by Prion Protein 