Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

Figure 4

BRCA2 mediates the cytotoxicity induced by gemcitabine. Impact of BRCA2 on the cellular sensitivity to gemcitabine was examined. BRCA2-deficient ovarian cancer cell line PE01 (closed square with dashed line) and pancreatic cancer cell line CAPAN1 (closed square with dashed line) are more resistant to gemcitabine compared to PE01(C4-2) (closed triangle) and CAPAN1 (C2-1) (closed triangle) that regain active BRCA2, respectively. Three independent experiments were performed and averages of surviving fraction are plotted. The error bars show standard deviations. The differences in the gemcitabine sensitivity between PE01 and PE01(C4-2), or CAPAN1 and CAPAN1(C2-1), are statistically significant with p<0.05.

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