Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect

Figure 7

Aberrant levels of SIDT1 suppress the naked ASO effect. SIDT1-overexpressing (a), normal (b), and SIDT1 knockdown (c) MEFs are shown. The numbers of ASO, SIDT1, and SIDT2 molecules reflect relative amounts among in those cells, and only the ASO molecules in the cytosol and the nucleosol are supposed to exert the antisense effect.

(a)

(b)

(c)