Journal of Nucleic Acids

Artificially Created Nucleic Acids and Peptides/Proteins in Chemical Biology


Publishing date
25 Jan 2013
Status
Published
Submission deadline
07 Sep 2012

1Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan

2Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8S 4K1

3Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902-6000, USA

4Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan


Artificially Created Nucleic Acids and Peptides/Proteins in Chemical Biology

Description

Nucleic acids are well known to have functions of preservation, transfer, and expression of genetic information. In addition, they can act as enzymes and specific binders in different processes of gene expression, as seen in ribozymes and riboswitches. The functions of nucleic acids can be modified and expanded using rational design and random screening methods. Furthermore, random screening method involving engineered genetic information systems can provide a novel class of peptides/proteins having nonnatural chemical structures, which is expected to enhance activities and confer additional functions. These artificially created biomolecules can be applicable to biosensors, diagnostic agents, and therapeutic drugs.

We invite authors to submit original research and review articles describing recent advances in creating the aforementioned biomolecules and their applications. We are particularly interested in articles that use chemical and evolutionary approach to develop functional nucleic acids and peptides/proteins. Potential topics include, but are not limited to:

  • Recent developments in methodologies for rational design, for example, chemically modified antigene/antisense nucleic acids, and siRNAs and miRNAs
  • Recent developments in methodologies for random screening, for example, in vitro selection of ribozymes, aptamers, aptazymes, peptides, and proteins
  • Correlation analysis of structures, thermodynamics, and functions
  • Unique features of unusual functions and their applications
  • Insertion of foreign groups and the effects on improvement and diversification of functions
  • Combinatorial design using multiple functional modules
  • In cell/in vivo applications toward bioanalysis and biomedicine

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jna/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 817350
  • - Review Article

Using Aptamers for Cancer Biomarker Discovery

Yun Min Chang | Michael J. Donovan | Weihong Tan
  • Special Issue
  • - Volume 2013
  • - Article ID 219263
  • - Editorial

Artificially Created Nucleic Acids and Peptides/Proteins in Chemical Biology

Masayasu Kuwahara | Yingfu Li | ... | Hiroshi Murakami
  • Special Issue
  • - Volume 2012
  • - Article ID 958683
  • - Review Article

Lighting Up RNA-Cleaving DNAzymes for Biosensing

Kha Tram | Pushpinder Kanda | Yingfu Li
  • Special Issue
  • - Volume 2012
  • - Article ID 748913
  • - Review Article

Challenges and Opportunities for Small Molecule Aptamer Development

Maureen McKeague | Maria C. DeRosa
  • Special Issue
  • - Volume 2012
  • - Article ID 215876
  • - Review Article

Dioxaphosphorinane-Constrained Nucleic Acid Dinucleotides as Tools for Structural Tuning of Nucleic Acids

Dan-Andrei Catana | Brice-Loïc Renard | ... | Jean-Marc Escudier
  • Special Issue
  • - Volume 2012
  • - Article ID 713510
  • - Review Article

Genetically Encoded Libraries of Nonstandard Peptides

Takashi Kawakami | Hiroshi Murakami
  • Special Issue
  • - Volume 2012
  • - Article ID 740982
  • - Review Article

Potential of Peptides as Inhibitors and Mimotopes: Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries

Teruhiko Matsubara
  • Special Issue
  • - Volume 2012
  • - Article ID 156482
  • - Review Article

Artificial Specific Binders Directly Recovered from Chemically Modified Nucleic Acid Libraries

Yuuya Kasahara | Masayasu Kuwahara
  • Special Issue
  • - Volume 2012
  • - Article ID 707323
  • - Research Article

Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

Tsuyoshi Yamamoto | Hidenori Yasuhara | ... | Satoshi Obika
  • Special Issue
  • - Volume 2012
  • - Article ID 962652
  • - Research Article

Imaging mRNA Expression in Live Cells via PNA·DNA Strand Displacement-Activated Probes

Zhenghui Wang | Ke Zhang | ... | John-Stephen Taylor
Journal of Nucleic Acids
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