Journal of Nucleic Acids

Synthesis and Application of Functional Nucleic Acids


Publishing date
15 Oct 2011
Status
Published
Submission deadline
15 Apr 2011

Lead Editor

1Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20, Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

2Physics Department E14, Technical University Munich, James-Franck-Straße, 85748 Garching, Germany

3Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology (CSIR), Mall Road, New Delhi, India

4Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6025, USA


Synthesis and Application of Functional Nucleic Acids

Description

The main biological function of nucleic acids is to store and transmit genetic information required for life. However, both DNA and RNA can serve purposes beyond genetic storage and transfer. They can display catalytic activity for various chemical reactions, binding affinity for diverse molecules, and responsiveness for chemical stimuli. Since the discovery of naturally occurring catalytic RNA (ribozymes) in the 1980s, RNA molecules with certain functions have been discovered in nature, selected from random pools, or designed rationally. Although no natural DNA catalysts have been reported, many artificial deoxyribozymes and DNA aptamers have been described. In addition, DNA and RNA switches have been discovered in nature and developed to regulate biological and chemical reactions. These functional nucleic acids have been employed for a broad spectrum of applications in biotechnology. Moreover, functional nucleic acids are opening new avenues for nanotechnology ranging from biosensors to computation. We believe that the time is ripe in this related research area to expand functions of nucleic acids and to explore new directions for functional nucleic acids.

This special issue will focus on the synthesis and application of functional nucleic acids. We invite authors to submit original research as well as review articles of recent topics related to nucleic acids with functionalities. Chemical synthesis and characterization of nucleic acids also would be of great interest. Potential topics include, but are not limited to:

  • Rational or evolutionary design of functional nucleic acids
  • Chemical synthesis and modification of nucleic acids
  • New methodologies for the development of functional nucleic acids
  • (Deoxy)ribozymes
  • DNA and RNA aptamers
  • (Deoxy)riboswitches
  • Structure-function relationship of nucleic acids
  • Higher-order structure of nucleic acids
  • Functional nucleic acids in biotechnology
  • Functional nucleic acids in nanotechnology
  • Biophysical and biochemical studies of nucleic acids

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jna/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 547245
  • - Editorial

Synthesis and Application of Functional Nucleic Acids

Daisuke Miyoshi | Friedrich C. Simmel | ... | Luis A. Marky
  • Special Issue
  • - Volume 2011
  • - Article ID 720798
  • - Research Article

A ssDNA Aptamer That Blocks the Function of the Anti-FLAG M2 Antibody

Amanda S. Lakamp | Michel M. Ouellette
  • Special Issue
  • - Volume 2011
  • - Article ID 805253
  • - Research Article

Synthesis of Specifically Modified Oligonucleotides for Application in Structural and Functional Analysis of RNA

Nico Rublack | Hien Nguyen | ... | Sabine Müller
  • Special Issue
  • - Volume 2011
  • - Article ID 623095
  • - Review Article

tRNA Modification and Genetic Code Variations in Animal Mitochondria

Kimitsuna Watanabe | Shin-ichi Yokobori
  • Special Issue
  • - Volume 2011
  • - Article ID 926595
  • - Research Article

Coupling Strategies for the Synthesis of Peptide-Oligonucleotide Conjugates for Patterned Synthetic Biomineralization

Joshua D. Carter | Thomas H. LaBean
  • Special Issue
  • - Volume 2011
  • - Article ID 724215
  • - Review Article

Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases

Sudha Sharma
  • Special Issue
  • - Volume 2011
  • - Article ID 857149
  • - Research Article

The Effects of Molecular Crowding on the Structure and Stability of G-Quadruplexes with an Abasic Site

Takeshi Fujimoto | Shu-ichi Nakano | ... | Naoki Sugimoto
  • Special Issue
  • - Volume 2011
  • - Article ID 162452
  • - Research Article

Photoswitching of Site-Selective RNA Scission by Sequential Incorporation of Azobenzene and Acridine Residues in a DNA Oligomer

Akinori Kuzuya | Keita Tanaka | Makoto Komiyama
  • Special Issue
  • - Volume 2011
  • - Article ID 471843
  • - Research Article

Triplet Analysis That Identifies Unpaired Regions of Functional RNAs

Junji Kawakami | Yoshie Yamaguchi | Naoki Sugimoto
  • Special Issue
  • - Volume 2011
  • - Article ID 360954
  • - Research Article

A Structurally Variable Hinged Tetrahedron Framework from DNA Origami

David M. Smith | Verena Schüller | ... | Tim Liedl
Journal of Nucleic Acids
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