Journal of Nucleic Acids

DNA Damage, Mutagenesis, and DNA Repair


Publishing date
15 Oct 2010
Status
Published
Submission deadline
15 Jun 2010

Lead Editor

1Department of Chemistry, University of Connecticut, Storrs, CT, USA

2Department of Biology, New York University, New York, NY, USA

3Division of Chemistry, Graduate School of Engineering Science, Osaka University, Osaka, Japan

4Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Würzburg, Germany


DNA Damage, Mutagenesis, and DNA Repair

Description

The consequences of DNA damage have been the subject of numerous studies in the last few decades. Replication of damaged DNA may result in an increased rate of mutations in the progeny, which may impart deleterious consequence on the organism. Various types of cancers have been linked to DNA damages and it is believed that the initiation of carcinogenesis may result from misreplication of the damaged DNA. DNA repair systems maintain the integrity of the genome by removing the damaged base, sugar, or phosphate from the DNA. In humans, specific DNA repair deficiencies have been associated with elevated risks of diseases, notably cancer, which underscores the importance of DNA repair. DNA damage is also known to induce lesion bypass polymerases which are error-prone on undamaged DNA and may bypass lesions in error-free or error-prone manners. The recent discovery of this new Y-family of DNA polymerases, their interactions with the lesions as determined by structural studies, and advances in the area of DNA repair have provided new insights on replicative and repair processes and their ultimate impact on mutagenesis. We believe that the time is ripe in this area of nucleic acids research to evaluate the current state of this field and to explore new research directions.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts to define the connections between research in relevant areas and human diseases. We are particularly interested in manuscripts that report mechanisms of mutation or repair processes, kinetics, mechanisms, and structures of dNTP incorporation opposite a lesion by DNA polymerases, as well as binding and removal of a defined lesion by purified repair proteins.

Potential topics include but are not limited to:

  • Endogenous DNA damages
  • DNA adducts or lesions formed by chemicals, radiation, or drugs
  • Development of probes to evaluate damage to nucleic acids
  • Biomarkers of human exposure
  • Base or nucleotide excision repair
  • X-, B-, or Y-Family DNA polymerases and their interaction with DNA lesions
  • Structure-function relationship in miscoding
  • Kinetic analysis of translesion synthesis

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jna/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 182894
  • - Editorial

DNA Damage, Mutagenesis, and DNA Repair

Ashis Basu | Suse Broyde | ... | Caroline Kisker
  • Special Issue
  • - Volume 2010
  • - Article ID 709521
  • - Review Article

Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts

Bo Hang
  • Special Issue
  • - Volume 2010
  • - Article ID 929047
  • - Review Article

The Biological and Metabolic Fates of Endogenous DNA Damage Products

Simon Wan Chan | Peter C. Dedon
  • Special Issue
  • - Volume 2010
  • - Article ID 592980
  • - Review Article

Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair

Rajesh P. Rastogi | Richa | ... | Rajeshwar P. Sinha
  • Special Issue
  • - Volume 2010
  • - Article ID 631595
  • - Review Article

Kinetic Approaches to Understanding the Mechanisms of Fidelity of the Herpes Simplex Virus Type 1 DNA Polymerase

Yali Zhu | Jason Stroud | ... | Deborah S. Parris
  • Special Issue
  • - Volume 2010
  • - Article ID 304035
  • - Research Article

Targeting the OB-Folds of Replication Protein A with Small Molecules

Victor J. Anciano Granadillo | Jennifer N. Earley | ... | John J. Turchi
  • Special Issue
  • - Volume 2010
  • - Article ID 456487
  • - Research Article

Aflatoxin B1-Associated DNA Adducts Stall S Phase and Stimulate Rad51 foci in Saccharomyces cerevisiae

Michael Fasullo | Yifan Chen | ... | Patricia A. Egner
  • Special Issue
  • - Volume 2010
  • - Article ID 750296
  • - Research Article

Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

Jun Takezawa | Yukio Ishimi | ... | Kouichi Yamada
  • Special Issue
  • - Volume 2010
  • - Article ID 543531
  • - Review Article

DNA Damage Induced by Alkylating Agents and Repair Pathways

Natsuko Kondo | Akihisa Takahashi | ... | Takeo Ohnishi
  • Special Issue
  • - Volume 2010
  • - Article ID 541050
  • - Research Article

Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?

Satomi Kawaguchi | Takanori Nakamura | ... | Yu F. Sasaki
Journal of Nucleic Acids
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