Table of Contents
Journal of Neurodegenerative Diseases
Volume 2013, Article ID 257953, 7 pages
Research Article

P-Glycoprotein Altered Expression in Alzheimer's Disease: Regional Anatomic Variability

1Department of Community Health Sciences, Faculty of Applied Health Sciences, Brock University, 500 Glenridge Avenue, St. Catharines, ON, Canada L2S 3A1
2Department of Pathology & Molecular, Medicine [Neuropathology], Hamilton Health Sciences, McMaster University, Hamilton, 1280 Main Street West, Hamilton, ON, L8S4L8, Canada

Received 14 January 2013; Revised 25 February 2013; Accepted 13 March 2013

Academic Editor: Seishi Terada

Copyright © 2013 Brian Jeynes and John Provias. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We investigated the expression of P-glycoprotein (P-gp) in brain samples of Alzheimer disease (AD) and normative brains (NM). Superior temporal cortex hippocampal and brainstem samples from 15 AD and NM brains were selected from comparable sites. P-gp positive capillaries and β-amyloid (Aβ) senile plaques (SP) were counted. Statistical analysis of the data was performed using nonparametric data analysis with Mann-Whitney, Kruskal-Wallis, and Spearman’s tests. There were no significant differences in P-gp expression between superior temporal and hippocampus samples. However, there were significant differences in P-gp expression, when comparing brainstem with both hippocampal and superior temporal samples in both conditions ( ; in NM cases and ; in AD cases); the brainstem has greater P-gp expression in each case and condition. In addition, there was a notable inverse negative correlation ( ) between P-gp expression and the presence of SPs in the AD condition superior temporal cortex. The results of this study suggest that there were significant site-dependent differences in the expression of P-gp. There may be an increased protective role for P-gp expression against amyloid deposition in the brainstem and in the superior temporal cortex of AD brains.