Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra
Effect of EX-(9-39) or NAF on recovery of striatal extracellular DA by EX-4 in 6-OHDA-lesioned rats. Both antagonists were coadministered with EX-4 twice daily for seven days, one week after toxin. Bar at 90–120 min indicates infusion of 100 mM K+. Results were analyzed using two-way ANOVA ( between treatments and 43.52 overtime) and a post hoc Bonferroni multiple comparisons test. All basal and evoked 6-OHDA and EX-4 + either EX-(9-39) or NAF groups were significantly different () from shams or 6-OHDA + EX-4 at all time points.