Research Article

Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer’s Disease Patient

Figure 7

Effects of fibrillar Aβ peptides on ir-KP release from SH-SY5Y neurons. (a) Neuronal SH-SY5Y cell cultures were exposed to fibrillar Aβ 1–43, Aβ 1–42, Aβ 1–40, Aβ 1–38, Aβ 17–40, and Aβ 25–35 peptides (100 nM each) for 4 h. (b) Dose dependent release of ir-KP was determined by incubating SH-SY5Y cell cultures with fibrillar Aβ 1–42 (0–10 μM) for 4 h. The release of ir-KP into the cell culture media was determined by EIA. All results, as % control (media alone), are shown as the mean ± SEM ( ) (*: versus control (media alone); one-way ANOVA).
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879710.fig.007b
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