Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington’s Disease and Parkinson’s Disease Human Brains

Figure 1

PSD-95 expression in the human HD and PD hippocampus and striatum. (a) PSD-95 significantly increased in DG and area CA3 in HD and in the DG and area CA1 in PD. ^∗𝑃≤0.05. (b) PSD-95 significantly decreased in the HD striatum in both the CN (caudate nucleus) and Put (putamen). ^∗∗𝑃<0.005. (c) Representative images of PSD-95 immunostaining in the dentate gyrus, CA3 and CA1 hippocampal regions. (d) Representative images of PSD-95 immunostaining in the caudate nucleus and putamen. Scale bar 25 𝜇m. (e) High power example image of PSD-95 immunolabeling showing the somatic and dendritic localisation patterns.

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