Table of Contents
Journal of Neurodegenerative Diseases
Volume 2014, Article ID 938530, 14 pages
http://dx.doi.org/10.1155/2014/938530
Research Article

Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington’s Disease and Parkinson’s Disease Human Brains

1Department of Physiology, Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, New Zealand
2Department of Anatomy with Radiology, Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, New Zealand
3School of Pharmacy, Centre for Brain Research, University of Auckland, Private Bag 92019, Auckland, New Zealand

Received 13 August 2013; Revised 14 October 2013; Accepted 29 October 2013; Published 16 January 2014

Academic Editor: Eng King Tan

Copyright © 2014 C. Fourie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Top: Antibody specificity as determined by Western Blot analysis of PSD-95, SAP97, GluA2 and GluN1 in human hippocampus. Example Western Blots are shown for PSD-95 (showing a doublet at ~82kDa band), SAP97 (~140 kDa band), GluA2 (~98kDa band) and GluN1 (~110kDa band) [18,31,70-73] in human control hippocampus. Bottom: Quantitative Western Blot analysis of PSD-95, SAP97, GluA2 and GluN1 in human control (black bars) and HD (gray bars) hippocampus show similar changes to quantitation by immunohistochemistry. ∗p < 0.05. Example protein bands are shown for PSD-95 (showing a doublet at ~82kDa band), SAP97 (~140 kDa band), GluA2 (~98kDa band) and GluN1 (~110kDa band) in human control (left) and HD (right) hippocampus.

  1. Supplementary Figure