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Journal of Nanomaterials
Volume 2008, Article ID 543170, 5 pages
http://dx.doi.org/10.1155/2008/543170
Research Article

Fibronectin Adsorption to Nanopatterned Silicon Surfaces

1Electrical and Computer Engineering Department, Wayne State University, Detroit, MI 48202, USA
2Biomedical Engineering Department, Wayne State University, Detroit, MI 48202, USA
3Chemical Engineering and Material Science Department, Wayne State University, Detroit, MI 48202, USA
4Department of Mechanical Engineering, College of Engineering, Wayne State University, Detroit, MI 48202, USA

Received 14 September 2007; Accepted 26 December 2007

Academic Editor: Donglu Shi

Copyright © 2008 I. Salakhutdinov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The possibility of using surface topography for guidance of different biological molecules and cells is a relevant topic that can be applied to a wide research activity. This study investigated the adsorption of fibronectin to a diffraction grated silicon surface. The rectangular grating profile featured a controlled surface with 350 nm period and a corrugation depth of 90 nm. Results demonstrated that the controlled surface had a significantly positive effect on the fibronectin binding. Thus, nanoscale surface topography can enhance fibronectin binding.