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Journal of Nanomaterials
Volume 2008, Article ID 680897, 9 pages
Research Article

Production of L-Leucine Nanoparticles under Various Conditions Using an Aerosol Flow Reactor Method

1NanoMaterials Group, Laboratory of Physics, Helsinki University of Technology, P.O. Box 5100, 02150 Espoo, Finland
2VTT Biotechnology, P.O. Box 1000, 02044 VTT, Finland

Received 1 August 2007; Revised 3 April 2008; Accepted 22 May 2008

Academic Editor: Ali Eftekhari

Copyright © 2008 Anna Lähde et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have studied the formation of L-leucine nanoparticles under various conditions using an aerosol flow reactor method. Temperatures and L-leucine concentrations for the experiments were selected to vary the saturation conditions for L-leucine in the reactor. In the two extreme cases, L-leucine is either in (i) the condensed phase (110°C) or completely in (ii) the vapour phase (200°C) for all concentrations; (iii) at the intermediate temperature (150°C), the extent of evaporation of L-leucine depends notably on the concentration, and thus partial evaporation and production of residual particles are expected. The size distribution of particles and the particle morphology varied according to formation mechanism with the geometric mean diameter of the particles between 30 nm and 210 nm. Hollow, spherical particles were obtained with the droplet-to-particle method without vaporisation of L-leucine; whereas leafy-looking particles were produced by homogeneous nucleation of supersaturated L-leucine vapour and subsequent growth by heterogeneous vapour deposition.