Nanoencapsulation of Nimodipine in Novel Biocompatible Poly(propylene-co-butylene succinate) Aliphatic Copolyesters for Sustained Release

Table 4

Dissolution parameters for all formulations.

Formulation	Korsmeyer-Peppas		𝑅^2	Zero-Order 𝐾𝑜	𝑅^2	Higuchi 𝐾𝐻	𝑅^2	First-Order 𝐾0	𝑅^2	Hixon and Croweel 𝐾𝑆	𝑅^2
	(𝑛)	𝐾𝐾𝑃
	PPSu	0.75										0.3087±0.2407	0.9952	0.1073±0.2541	0.9851	0.7545±0.6250	0.9641	0.0012±0.4764	0.9793	0.0004±0.4878	0.9783
PPBSu 90/10 w/w	0.76	0.4398±0.2765	0.9972	0.1614±0.2684	0.9889	1.1281±0.9381	0.9640	0.0018±0.6113	0.9849	0.0006±0.6363	0.9836
PPBSu 80/20 w/w	0.85	0.3647±0.3883	0.9961	0.1942±0.3874	0.9934	1.2955±1.3728	0.9458	0.0022±0.4917	0.9932	0.0007±0.5197	0.9924
PPBSu 70/30 w/w	0.81	0.4825±0.2506	0.9987	0.2203±0.3411	0.9946	1.4995±1.4074	0.9558	0.0025±0.5489	0.9934	0.0008±0.5928	0.9923
PPBSu 60/40 w/w	0.84	0.3652±0.2581	0.9980	0.1815±0.2553	0.9966	1.2332±1.2031	0.9522	0.0020±0.4437	0.9936	0.0007±0.4649	0.9930
PPBSu 50/50 w/w	0.72	0.6567±0.2504	0.9986	0.2041±0.3.874	0.9853	1.4561±1.0464	0.9723	0.0024±0.8731	0.9808	0.0008±0.9185	0.9787