Cancer Therapy Based on Nanomaterials and Nanocarrier Systems

Table 1

Stimuli that can be utilized to control the behavior and properties of micelles.

Stimuli	Stimuli origin	Examples	References
pH	Decreased pH in cancer site caused by hypoxia and massive cell death	Tumoral acidic extracellular pH targeting of pH-responsive micelles encapsulated doxorubicin for cancer therapy	[31]
Temperature	Increased temperature in cancerous tissues owing to their high metabolic activities. External applied heating	Self-assembled, thermosensitive micelles for controlled doxorubicin delivery	[32]
Magnetic field	Locally applied magnetic field	Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells	[33]
Ultrasound	Locally applied ultrasound	Ultrasonic release of doxorubicin from pluronic P105 micelles	[28]
Redox potential	Increased concentration of glutathione inside many cancerous cells	Poly(ethylene glycol)-modified thiolated gelatin nanoparticles for glutathione-responsive intracellular DNA delivery	[34]