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Journal of Nanomaterials
Volume 2010, Article ID 818717, 7 pages
Research Article

An Insight into the Interactions between -Tocopherol and Chitosan in Ultrasound-Prepared Nanoparticles

1Department of Medical Nanotechnology, Faculty of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran 14174, Iran
2Department of Pharmaceutical Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran 14174, Iran
3Biotechnology Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran

Received 31 January 2010; Accepted 6 June 2010

Academic Editor: Doron Yadlovker

Copyright © 2010 Majid Naghibzadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate the interactions between -tocopherol and chitosan molecules prepared subsequent to preparation of -tocopherol-loaded chitosan nanoparticles using ultrasonication. Dynamic light scattering (DLS) and scanning electron microscopy (SEM) analyses showed semispherical particles with an average size of approximately 350 nm. Also from reconstitution test, -tocopherol was suggested as stabilizing agent during lyophilization/reconstitution process. The zeta potentials of chitosan and -tocopherol nanoparticles were larger than 30 mV, representing suitable stability. Data obtained from FTIR showed possibility of chemical interaction between chitosan and -tocopherol. Furthermore, the results from FTIR, NMR, and XRD spectroscopy confirmed electrostatic interactions between the two molecules. Overall, this procedure could be considered as a facile method to prepare -tocopherol-loaded nanoparticles.