Nanoconjugate Platforms Development Based in Poly(𝛽,L-Malic Acid) Methyl Esters for Tumor Drug Delivery

Table 1

Physical properties of copolymers.

	coPMLA-Me25	coPMLA-Me50
	H75	H50
Methylation(a) (%)	20.2	46.5
𝑀𝑤  (b)	32,600	33,100
𝑀𝑛  (b)	26,100	24,300
𝑇𝑚  (c) (∘C)	174	172
𝑇𝑑  (d) (∘C)	186	198
Microstructure(e)
Contiguous patches 𝑛^𝑓 Me	3.9	11.8
Contiguous patches 𝑛^𝑔 COOH	11.5	14.5
R	0.3	0.2

(a)Copolymer composition determined by 1H NMR; (b)Weight- and number-average molecular weight measured by sec-HPLC; (c)Melting temperature measured by differential scanning calorimetry; (d)Onset decomposition temperature measured at 5% of loss of initial weight; ^(e)𝑛^𝑓 and 𝑛^𝑔 refer to averaged numbers of methylated and free carboxyl group within homogeneous sequences, respectively, and (R) refers the randomness determined by 13C NMR analysis [11].