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Journal of Nanomaterials
Volume 2010, Article ID 898910, 5 pages
http://dx.doi.org/10.1155/2010/898910
Research Article

Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System

1College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
2College of Public Health, Guangdong Pharmaceutical University, Guangzhou 510240, China

Received 6 July 2009; Revised 1 September 2009; Accepted 1 November 2009

Academic Editor: Gaurav Mago

Copyright © 2010 Hong-liang Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Frokjaer and D. E. Otzen, “Protein drug stability: a formulation challenge,” Nature Reviews Drug Discovery, vol. 4, no. 4, pp. 298–306, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. B.-Y. Kim, J. H. Jeong, K. Park, and J.-D. Kim, “Bioadhesive interaction and hypoglycemic effect of insulin-loaded lectin-microparticle conjugates in oral insulin delivery system,” Journal of Controlled Release, vol. 102, no. 3, pp. 525–538, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. G. P. Carino, J. S. Jacob, and E. Mathiowitz, “Nanosphere based oral insulin delivery,” Journal of Controlled Release, vol. 65, no. 1-2, pp. 261–269, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Nakashima, M. Miyagi, K. Goto, Y. Matsumoto, and R. Ueoka, “Enzymatic and hyperglycemia stability of chemically modified insulins with hydrophobic acyl groups,” Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 2, pp. 481–483, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Ponchel and J.-M. Irache, “Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract,” Advanced Drug Delivery Reviews, vol. 34, no. 2-3, pp. 191–219, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Takeuchi, H. Yamamoto, and Y. Kawashima, “Mucoadhesive nanoparticulate systems for peptide drug delivery,” Advanced Drug Delivery Reviews, vol. 47, no. 1, pp. 39–54, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Sakuma, M. Hayashi, and M. Akashi, “Design of nanoparticles composed of graft copolymers for oral peptide delivery,” Advanced Drug Delivery Reviews, vol. 47, no. 1, pp. 21–37, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Sarmento, D. C. Ferreira, L. Jorgensen, and M. van de Weert, “Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 65, no. 1, pp. 10–17, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. F. Chen, Z.-R. Zhang, and Y. Huang, “Evaluation and modification of N-trimethyl chitosan chloride nanoparticles as protein carriers,” International Journal of Pharmaceutics, vol. 336, no. 1, pp. 166–173, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. K. A. Janes, P. Calvo, and M. J. Alonso, “Polysaccharide colloidal particles as delivery systems for macromolecules,” Advanced Drug Delivery Reviews, vol. 47, no. 1, pp. 83–97, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Paul and C. P. Sharma, “Chitosan, a drug carrier for the 21st century: a review,” S.T.P. Pharma Sciences, vol. 10, no. 1, pp. 5–22, 2000. View at Google Scholar · View at Scopus
  12. M. Thanou, J. C. Verhoef, and H. E. Junginger, “Oral drug absorption enhancement by chitosan and its derivatives,” Advanced Drug Delivery Reviews, vol. 52, no. 2, pp. 117–126, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Z. Shu and K. J. Zhu, “Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure,” International Journal of Pharmaceutics, vol. 233, no. 1-2, pp. 217–225, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Khor and L. Y. Lim, “Implantable applications of chitin and chitosan,” Biomaterials, vol. 24, no. 13, pp. 2339–2349, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Qian, F. Cui, J. Ding, C. Tang, and C. Yin, “Chitosan graft copolymer nanoparticles for oral protein drug delivery: preparation and characterization,” Biomacromolecules, vol. 7, no. 10, pp. 2722–2727, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. P. Calvo, C. Remuñán-López, J. L. Vila-Jato, and M. J. Alonso, “Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers,” Journal of Applied Polymer Science, vol. 63, no. 1, pp. 125–132, 1997. View at Google Scholar · View at Scopus
  17. J.-H. Yu, Y.-M. Du, and H. Zheng, “Blend films of chitosan-gelatin,” Wuhan University Journal of Natural Sciences, vol. 45, no. 4, pp. 440–444, 1999. View at Google Scholar · View at Scopus
  18. J. Z. Knaul, S. M. Hudson, and K. A. M. Creber, “Improved mechanical properties of chitosan fibers,” Journal of Applied Polymer Science, vol. 72, no. 13, pp. 1721–1732, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. R. J. Vandenberg and K. R. Aubrey, “Glycine transport inhibitors as potential antipsychotic drugs,” Expert Opinion on Therapeutic Targets, vol. 5, no. 4, pp. 507–518, 2001. View at Google Scholar · View at Scopus
  20. K. A. Janes and M. J. Alonso, “Depolymerized chitosan nanoparticles for protein delivery: preparation and characterization,” Journal of Applied Polymer Science, vol. 88, no. 12, pp. 2769–2776, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Grenha, B. Seijo, and C. Remuñán-López, “Microencapsulated chitosan nanoparticles for lung protein delivery,” European Journal of Pharmaceutical Sciences, vol. 25, no. 4-5, pp. 427–437, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. E. Leo, R. Cameroni, and F. Forni, “Dynamic dialysis for the drug release evaluation from doxorubicin-gelatin nanoparticle conjugates,” International Journal of Pharmaceutics, vol. 180, no. 1, pp. 23–30, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Lamprecht, N. Ubrich, M. H. Pérez, C.-M. Lehr, M. Hoffman, and P. Maincent, “Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique,” International Journal of Pharmaceutics, vol. 196, no. 2, pp. 177–182, 2000. View at Publisher · View at Google Scholar · View at Scopus