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Journal of Nanomaterials
Volume 2011, Article ID 105138, 8 pages
Research Article

Single Nucleotide Polymorphism Detection Using Au-Decorated Single-Walled Carbon Nanotube Field Effect Transistors

1NanoBio Fusion Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-343, Republic of Korea
2Regional Innovation Agency, Jeonbuk Technopark, Jeonju 561-844, Republic of Korea
3Panagene Inc., Daejeon 305-510, Republic of Korea
4Ucaretron Inc., Dongiltechno Building C, Anyang 431-716, Republic of Korea

Received 14 June 2010; Revised 3 September 2010; Accepted 10 September 2010

Academic Editor: Jianyu Huang

Copyright © 2011 Keum-Ju Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In Figure S1, we showed optical microscope images and AFM images of Au-decorated SWNT-FET. Figure S1(b) shows evolution of electronic transfer characteristics of SWNT-FET with Au decoration. Supplementary Figure S2 (a), (b), and (c) show confocal microscope images of Au-decorated ultra-long nanotubes with Cy-3 labeled PNA. It is possible to achieve a highly specific immobilization of probe PNA with 6 hrs incubation and thorough washing. Figure S3 also shows confocal microsope image and a SEM image of Au-decorated ultra-long nanotube. The figure displays that hybridization of target DNA occur mostly on Au nanoparticles. Figure S4 shows evolution of transfer characteristics from 5 different devices upon immobilization of Au, probe PNA, and hybridization of DNA. In Figure S5, we showed the results from control hybridization experiments with non-specifically adsorbed probe PNA. Change of conductance upon hybridization show little consistency in this case.

  1. Supplementary Material