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Journal of Nanomaterials
Volume 2011, Article ID 201834, 7 pages
http://dx.doi.org/10.1155/2011/201834
Research Article

Electrospinning of Poly(ethylene-co-vinyl alcohol) Nanofibres Encapsulated with Ag Nanoparticles for Skin Wound Healing

Chao Xu,1,2 Feng Xu,1,3 Bin Wang,1,2 and TianJian Lu1

1Biomedical Engineering and Biomechanics Center, School of Aerospace, Xi'an Jiaotong University, Xi'an 710049, China
2School of Engineering, University of Aberdeen, Aberdeen AB24 3UE, UK
3Department of Medicine, HST-Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA

Received 2 November 2010; Revised 14 December 2010; Accepted 17 December 2010

Academic Editor: Zuwei Ma

Copyright © 2011 Chao Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Skin wound healing is an urgent problem in clinics and military activities. Although significant advances have been made in its treatment, there are several challenges associated with traditional methods, for example, limited donor skin tissue for transplantation and inflammation during long-term healing time. To address these challenges, in this study we present a method to fabricate Poly(ethylene-co-vinyl alcohol) (EVOH) nanofibres encapsulated with Ag nanoparticle using electrospinning technique. The fibres were fabricated with controlled diameters (59 nm–3 μm) by regulating three main parameters, that is, EVOH solution concentration, the electric voltage, and the distance between the injection needle tip (high-voltage point) and the fibre collector. Ag was added to the nanofibres to offer long-term anti-inflammation effect by slow release of Ag nanoparticles through gradual degradation of EVOH nanofibre. The method developed here could lead to new dressing materials for treatment of skin wounds.