Table 4: Solubility of drugs in SEDDS.

NO.FormulaKmOil : SmixSKeto (mg·mL−1)SIbu (mg·mL−1) (mg·mL−1)SNap (mg·mL−1) (mg·mL−1) (mg·mL−1)

1a11 : 20.5 : 9.50.9611.7560.8480.3321.9090.989
2a11 : 21 : 91.2072.0750.9480.3502.0021.014
3a11 : 21.5 : 8.51.4392.6341.0140.3662.4221.086
4a11 : 10.5 : 9.51.5192.2931.0540.4232.0721.139
5b11 : 11 : 91.4642.5521.1990.4262.1441.146
6a11 : 11.5 : 8.51.8642.9581.3150.4202.4311.321
7a12 : 10.5 : 9.51.8252.4361.4420.5532.1311.502
8a12 : 11 : 91.9432.9951.5410.5542.2091.594
9b12 : 11.5 : 8.51.6743.2211.5640.5522.4571.689
10a13 : 10.5 : 9.52.0332.6781.5350.5922.1771.633
11a13 : 11 : 92.3543.061.5980.5942.3871.605
12a13 : 11.5 : 8.52.4853.3551.7050.5692.4991.757
13b14 : 10.5 : 9.52.1552.7621.5410.5962.3551.842
14a14 : 11 : 92.4383.1121.6470.6182.4971.871
15a14 : 11.5 : 8.52.2203.5201.7140.5822.5101.799
16a21 : 20.5 : 9.50.7981.5380.9330.3971.5220.957
17a21 : 21 : 90.8451.8990.9580.4031.5630.964
18a21 : 21.5 : 8.50.8562.1641.0420.3901.4750.956
19b21 : 10.5 : 9.51.0572.0741.0450.4501.9041.475
20a21 : 11 : 91.2952.4441.2280.4661.9281.498
21a21 : 11.5 : 8.51.1962.5771.5350.5141.8771.491
22a22 : 10.5 : 9.51.4382.6081.4650.6092.1651.777
23a22 : 11 : 91.3532.8241.5690.6202.0911.836
24a22 : 11.5 : 8.51.4303.0991.6660.6312.1861.88
25a23 : 10.5 : 9.51.5772.7061.7160.6472.2151.923
26a23 : 11 : 91.6653.0661.7400.6462.0822.103
27b23 : 11.5 : 8.51.6003.4181.8300.6962.2292.009
28a24 : 10.5 : 9.51.6372.7701.7490.7032.3102.165
29a24 : 11 : 91.7053.1761.7910.6942.2682.171
30a24 : 11.5 : 8.51.6403.8161.9590.7152.3582.113
31a31 : 20.5 : 9.50.8401.4950.8390.4141.4831.378
32b31 : 21 : 91.0182.3561.0150.4371.6531.405
33a31 : 21.5 : 8.51.0272.4321.0300.3991.7711.407
34a31 : 10.5 : 9.51.2172.2431.2020.5871.9301.903
35a31 : 11 : 91.1832.4071.2440.5301.9371.894
36b31 : 11.5 : 8.51.3302.9181.3000.4972.1001.939
37a32 : 10.5 : 9.51.5372.5731.3930.6372.3312.307
38a32 : 11 : 91.7393.1481.6380.6272.3962.404
39b32 : 11.5 : 8.51.6313.3521.6700.6242.3392.366
40a33 : 10.5 : 9.51.7463.0591.6440.6512.5522.637
41a33 : 11 : 91.8033.4941.7520.6802.4582.659
42a33 : 11.5 : 8.51.7553.6741.8260.7052.3442.46
43a34 : 10.5 : 9.51.9353.2161.8150.7652.6062.714
44a34 : 11 : 91.8743.5541.8310.7392.6082.757
45a34 : 11.5 : 8.52.0333.6872.0120.7492.4392.676
46b41 : 20.5 : 9.50.9441.5450.7940.3421.5850.818
47a41 : 21 : 90.9611.9690.9500.3591.4260.729
48a41 : 21.5 : 8.50.9802.4480.9850.3451.4890.853
49a41 : 10.5 :  9.51.3022.2191.0470.4381.8441.102
50a41 : 11 : 91.3162.7541.1340.4761.7221.262
51a41 : 11.5 : 8.51.4513.1371.3100.4412.1361.103
52b42 : 10.5 : 9.51.6712.231.0710.4442.0811.553
53a42 : 11 : 91.7112.7821.3510.4842.0531.642
54a42 : 11.5 : 8.51.8633.3281.3160.4422.4221.496
55b43 : 10.5 : 9.51.9622.4831.0950.4552.1331.725
56a43 : 11 : 92.0063.1721.3560.4892.4471.663
57a43 : 11.5 : 8.52.1303.9461.3440.4612.4701.801
58a44 : 10.5 : 9.52.0922.5451.1680.4582.4271.94
59b44 : 11 : 92.1243.3801.3850.5032.5191.892
60a44 : 11.5 : 8.51.9994.0621.4310.4912.6391.945
61a51 : 20.5 : 9.50.8161.6090.9210.4421.6060.807
62b51 : 21 : 90.8542.0170.9800.4401.6491.208
63a51 : 21.5 : 8.50.8762.1011.0020.4231.7011.273
64a51 : 10.5 : 9.50.9851.9451.3440.5251.9451.577
65a51 : 11 : 91.2272.2111.3430.5612.0011.646
66a51 : 11.5 : 8.51.2462.7131.4240.5482.0641.699
67a52 : 10.5 : 9.51.3982.6621.5440.6892.1342.134
68b52 : 11 : 91.6102.8531.6780.6782.2862.010
69a52 : 11.5 : 8.51.6173.3071.8190.6552.4192.199
70a53 : 10.5 : 9.51.5582.9321.7740.7352.2682.256
71a53 : 11 : 91.7473.2601.6980.6932.3552.416
72b53 : 11.5 : 8.51.7913.6171.8410.6942.4952.300
73a54 : 10.5 : 9.51.6172.9851.8200.7662.3372.454
74a54 : 11 : 91.9213.3931.9530.7602.3742.505
75a54 : 11.5 : 8.51.8123.6852.0550.7522.5032.429
76a61 : 20.5 : 9.50.8391.7690.8490.3811.5441.439
77b61 : 21 : 90.9062.1630.9510.3711.6651.32
78a61 : 21.5 : 8.51.0662.4141.1350.4021.7121.392
79a61 : 10.5 : 9.51.2372.2031.2420.4851.7941.759
80a61 : 11 : 91.5372.3491.2990.5101.8691.811
81a61 : 11.5 : 8.51.5132.9381.5270.5401.9621.88
82a62 : 10.5 : 9.51.5812.4551.4370.6361.9122.331
83b62 : 11 : 91.7112.6861.5590.6312.0692.258
84a62 : 11.5 : 8.51.7213.0681.7280.6562.1432.406
85b63 : 10.5 : 9.51.7682.7101.6470.6682.2952.500
86a63 : 11 : 91.9803.2651.7750.6592.6522.657
87a63 : 11.5 :  8.51.9493.7091.9240.6862.5952.421
88a64 : 10.5 : 9.51.9593.2561.7810.6852.5722.728
89a64 : 11 : 91.9843.6461.8600.6942.7292.806
90a64 : 11.5 : 8.52.1553.7422.0690.7252.7982.793

aTraining set.
bInternal validation set.