Development of Quantitative Structure-Property Relationship Models for Self-Emulsifying Drug Delivery System of 2-Aryl Propionic Acid NSAIDs

Table 4

Solubility of drugs in SEDDS.

NO.	Formula	Km	Oil : Smix	SKeto (mg·mL^−1)	SIbu (mg·mL^−1)	SFlu(mg·mL^−1)	SNap (mg·mL^−1)	SLoxo(mg·mL^−1)	Scar(mg·mL^−1)
1^a	1	1 : 2	0.5 : 9.5	0.961	1.756	0.848	0.332	1.909	0.989
2^a	1	1 : 2	1 : 9	1.207	2.075	0.948	0.350	2.002	1.014
3^a	1	1 : 2	1.5 : 8.5	1.439	2.634	1.014	0.366	2.422	1.086
4^a	1	1 : 1	0.5 : 9.5	1.519	2.293	1.054	0.423	2.072	1.139
5^b	1	1 : 1	1 : 9	1.464	2.552	1.199	0.426	2.144	1.146
6^a	1	1 : 1	1.5 : 8.5	1.864	2.958	1.315	0.420	2.431	1.321
7^a	1	2 : 1	0.5 : 9.5	1.825	2.436	1.442	0.553	2.131	1.502
8^a	1	2 : 1	1 : 9	1.943	2.995	1.541	0.554	2.209	1.594
9^b	1	2 : 1	1.5 : 8.5	1.674	3.221	1.564	0.552	2.457	1.689
10^a	1	3 : 1	0.5 : 9.5	2.033	2.678	1.535	0.592	2.177	1.633
11^a	1	3 : 1	1 : 9	2.354	3.06	1.598	0.594	2.387	1.605
12^a	1	3 : 1	1.5 : 8.5	2.485	3.355	1.705	0.569	2.499	1.757
13^b	1	4 : 1	0.5 : 9.5	2.155	2.762	1.541	0.596	2.355	1.842
14^a	1	4 : 1	1 : 9	2.438	3.112	1.647	0.618	2.497	1.871
15^a	1	4 : 1	1.5 : 8.5	2.220	3.520	1.714	0.582	2.510	1.799
16^a	2	1 : 2	0.5 : 9.5	0.798	1.538	0.933	0.397	1.522	0.957
17^a	2	1 : 2	1 : 9	0.845	1.899	0.958	0.403	1.563	0.964
18^a	2	1 : 2	1.5 : 8.5	0.856	2.164	1.042	0.390	1.475	0.956
19^b	2	1 : 1	0.5 : 9.5	1.057	2.074	1.045	0.450	1.904	1.475
20^a	2	1 : 1	1 : 9	1.295	2.444	1.228	0.466	1.928	1.498
21^a	2	1 : 1	1.5 : 8.5	1.196	2.577	1.535	0.514	1.877	1.491
22^a	2	2 : 1	0.5 : 9.5	1.438	2.608	1.465	0.609	2.165	1.777
23^a	2	2 : 1	1 : 9	1.353	2.824	1.569	0.620	2.091	1.836
24^a	2	2 : 1	1.5 : 8.5	1.430	3.099	1.666	0.631	2.186	1.88
25^a	2	3 : 1	0.5 : 9.5	1.577	2.706	1.716	0.647	2.215	1.923
26^a	2	3 : 1	1 : 9	1.665	3.066	1.740	0.646	2.082	2.103
27^b	2	3 : 1	1.5 : 8.5	1.600	3.418	1.830	0.696	2.229	2.009
28^a	2	4 : 1	0.5 : 9.5	1.637	2.770	1.749	0.703	2.310	2.165
29^a	2	4 : 1	1 : 9	1.705	3.176	1.791	0.694	2.268	2.171
30^a	2	4 : 1	1.5 : 8.5	1.640	3.816	1.959	0.715	2.358	2.113
31^a	3	1 : 2	0.5 : 9.5	0.840	1.495	0.839	0.414	1.483	1.378
32^b	3	1 : 2	1 : 9	1.018	2.356	1.015	0.437	1.653	1.405
33^a	3	1 : 2	1.5 : 8.5	1.027	2.432	1.030	0.399	1.771	1.407
34^a	3	1 : 1	0.5 : 9.5	1.217	2.243	1.202	0.587	1.930	1.903
35^a	3	1 : 1	1 : 9	1.183	2.407	1.244	0.530	1.937	1.894
36^b	3	1 : 1	1.5 : 8.5	1.330	2.918	1.300	0.497	2.100	1.939
37^a	3	2 : 1	0.5 : 9.5	1.537	2.573	1.393	0.637	2.331	2.307
38^a	3	2 : 1	1 : 9	1.739	3.148	1.638	0.627	2.396	2.404
39^b	3	2 : 1	1.5 : 8.5	1.631	3.352	1.670	0.624	2.339	2.366
40^a	3	3 : 1	0.5 : 9.5	1.746	3.059	1.644	0.651	2.552	2.637
41^a	3	3 : 1	1 : 9	1.803	3.494	1.752	0.680	2.458	2.659
42^a	3	3 : 1	1.5 : 8.5	1.755	3.674	1.826	0.705	2.344	2.46
43^a	3	4 : 1	0.5 : 9.5	1.935	3.216	1.815	0.765	2.606	2.714
44^a	3	4 : 1	1 : 9	1.874	3.554	1.831	0.739	2.608	2.757
45^a	3	4 : 1	1.5 : 8.5	2.033	3.687	2.012	0.749	2.439	2.676
46^b	4	1 : 2	0.5 : 9.5	0.944	1.545	0.794	0.342	1.585	0.818
47^a	4	1 : 2	1 : 9	0.961	1.969	0.950	0.359	1.426	0.729
48^a	4	1 : 2	1.5 : 8.5	0.980	2.448	0.985	0.345	1.489	0.853
49^a	4	1 : 1	0.5 :  9.5	1.302	2.219	1.047	0.438	1.844	1.102
50^a	4	1 : 1	1 : 9	1.316	2.754	1.134	0.476	1.722	1.262
51^a	4	1 : 1	1.5 : 8.5	1.451	3.137	1.310	0.441	2.136	1.103
52^b	4	2 : 1	0.5 : 9.5	1.671	2.23	1.071	0.444	2.081	1.553
53^a	4	2 : 1	1 : 9	1.711	2.782	1.351	0.484	2.053	1.642
54^a	4	2 : 1	1.5 : 8.5	1.863	3.328	1.316	0.442	2.422	1.496
55^b	4	3 : 1	0.5 : 9.5	1.962	2.483	1.095	0.455	2.133	1.725
56^a	4	3 : 1	1 : 9	2.006	3.172	1.356	0.489	2.447	1.663
57^a	4	3 : 1	1.5 : 8.5	2.130	3.946	1.344	0.461	2.470	1.801
58^a	4	4 : 1	0.5 : 9.5	2.092	2.545	1.168	0.458	2.427	1.94
59^b	4	4 : 1	1 : 9	2.124	3.380	1.385	0.503	2.519	1.892
60^a	4	4 : 1	1.5 : 8.5	1.999	4.062	1.431	0.491	2.639	1.945
61^a	5	1 : 2	0.5 : 9.5	0.816	1.609	0.921	0.442	1.606	0.807
62^b	5	1 : 2	1 : 9	0.854	2.017	0.980	0.440	1.649	1.208
63^a	5	1 : 2	1.5 : 8.5	0.876	2.101	1.002	0.423	1.701	1.273
64^a	5	1 : 1	0.5 : 9.5	0.985	1.945	1.344	0.525	1.945	1.577
65^a	5	1 : 1	1 : 9	1.227	2.211	1.343	0.561	2.001	1.646
66^a	5	1 : 1	1.5 : 8.5	1.246	2.713	1.424	0.548	2.064	1.699
67^a	5	2 : 1	0.5 : 9.5	1.398	2.662	1.544	0.689	2.134	2.134
68^b	5	2 : 1	1 : 9	1.610	2.853	1.678	0.678	2.286	2.010
69^a	5	2 : 1	1.5 : 8.5	1.617	3.307	1.819	0.655	2.419	2.199
70^a	5	3 : 1	0.5 : 9.5	1.558	2.932	1.774	0.735	2.268	2.256
71^a	5	3 : 1	1 : 9	1.747	3.260	1.698	0.693	2.355	2.416
72^b	5	3 : 1	1.5 : 8.5	1.791	3.617	1.841	0.694	2.495	2.300
73^a	5	4 : 1	0.5 : 9.5	1.617	2.985	1.820	0.766	2.337	2.454
74^a	5	4 : 1	1 : 9	1.921	3.393	1.953	0.760	2.374	2.505
75^a	5	4 : 1	1.5 : 8.5	1.812	3.685	2.055	0.752	2.503	2.429
76^a	6	1 : 2	0.5 : 9.5	0.839	1.769	0.849	0.381	1.544	1.439
77^b	6	1 : 2	1 : 9	0.906	2.163	0.951	0.371	1.665	1.32
78^a	6	1 : 2	1.5 : 8.5	1.066	2.414	1.135	0.402	1.712	1.392
79^a	6	1 : 1	0.5 : 9.5	1.237	2.203	1.242	0.485	1.794	1.759
80^a	6	1 : 1	1 : 9	1.537	2.349	1.299	0.510	1.869	1.811
81^a	6	1 : 1	1.5 : 8.5	1.513	2.938	1.527	0.540	1.962	1.88
82^a	6	2 : 1	0.5 : 9.5	1.581	2.455	1.437	0.636	1.912	2.331
83^b	6	2 : 1	1 : 9	1.711	2.686	1.559	0.631	2.069	2.258
84^a	6	2 : 1	1.5 : 8.5	1.721	3.068	1.728	0.656	2.143	2.406
85^b	6	3 : 1	0.5 : 9.5	1.768	2.710	1.647	0.668	2.295	2.500
86^a	6	3 : 1	1 : 9	1.980	3.265	1.775	0.659	2.652	2.657
87^a	6	3 : 1	1.5 :  8.5	1.949	3.709	1.924	0.686	2.595	2.421
88^a	6	4 : 1	0.5 : 9.5	1.959	3.256	1.781	0.685	2.572	2.728
89^a	6	4 : 1	1 : 9	1.984	3.646	1.860	0.694	2.729	2.806
90^a	6	4 : 1	1.5 : 8.5	2.155	3.742	2.069	0.725	2.798	2.793

^aTraining set.
^bInternal validation set.