Optimization of the Preparation Process for an Oral Phytantriol-Based Amphotericin B Cubosomes

Table 1

Results of particle size measurement on three batches of blank cubosome dispersions prepared under different homogenization conditions.

Cubosome dispersion	Mean particle size (nm)	PDI
Ultrasound only	291.70 ± 37.40	0.250 ± 0.030
600 bar for 3 cycles	290.00 ± 25.00	0.210 ± 0.024
600 bar for 6 cycles	277.33 ± 4.16	0.191 ± 0.027
600 bar for 9 cycles	275.33 ± 18.82	0.189 ± 0.009
1200 bar for 3 cycles	259.66 ± 19.30	0.162 ± 0.010
1200 bar for 6 cycles	259.67 ± 12.42	0.149 ± 0.027
1200 bar for 9 cycles	241.00 ± 12.42	0.107 ± 0.027
1800 bar for 9 cycles	248.67 ± 4.93	0.103 ± 0.016