Electrospun Collagen: A Tissue Engineering Scaffold with Unique Functional Properties in a Wide Variety of Applications
Figure 4
Dermal Reconstruction. Healing response to electrospun collagen (a)–(c) and electrospun gelatin (d)–(f) as a function of fiber diameter and pore dimension. Collagen-based implants exhibited a smooth continuum of cells at the interface of the lesion and the surrounding tissue. In each of the images depicted in this figure, native, uninjured tissue appears to the left of each data image (delineated by the large blue staining collagen bundles in the histological preparations, arrows (b) and (c)). Gelatin based-scaffolds were consistently less heavily infiltrated and exhibited evidence of an inflammatory response and accumulated foreign body giant cells (arrow head (d)). (a) and (d) average fiber diameter = 240–280 nm, average pore dimension =1500–2000 nm2, (b) and (e) average fiber diameter 500–600 nm, average pore dimension 3000–5000 nm2, (c) and (f) average fiber diameter 800–1000 nm, average pore dimension 4000–5000 nm.
