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Journal of Nanomaterials
Volume 2011 (2011), Article ID 528628, 11 pages
Research Article

Montmorillonite Clay-Based Polyurethane Nanocomposite As Local Triamcinolone Acetonide Delivery System

1School of Pharmacy, Federal University of São João Del Rei, MG 35.501-296, Divinópolis, Brazil
2School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
3Department of Materials, Technologies and Processes, Minas Gerais State University, Belo Horizonte, MG, Brazil
4Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

Received 17 May 2011; Revised 6 July 2011; Accepted 12 July 2011

Academic Editor: Donglu Shi

Copyright © 2011 Flávia Carmo Horta Pinto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biodegradable polyurethane was synthesized by preparing aqueous polyurethane dispersion having poly(caprolactone) and poly(ethylene glycol) as soft segments. Montmorillonite particles were delaminated within the waterborne polyurethane to produce a nanocomposite. The triamcinolone acetonide (TA), an important corticoid drug, was dispersed into the nanocomposite followed by a drying step to produce an implantable drug delivery system. Infrared (FTIR) results demonstrated that the original chemical structure of the TA was preserved after incorporation into the nanocomposite. Wide angle (WAXS) and small angle X-ray scattering (SAXS) results suggested that TA and clay do not dramatically change the morphology phase of the polymer although they can interact with each other. The presence of montmorillonite particles in the nanocomposite reduced the rate of TA release as compared to the pure polyurethane and enhanced the mechanical properties of the polymer. The overall results indicate that montmorillonite clay-based polyurethane nanocomposite could be potentially applied as local TA delivery system.