TY - JOUR
A2 - Phuruangrat, Anukorn
AU - Ren, Wen Ting
AU - Liang, Liang Bo
AU - Qi, Fei
AU - Sun, Zheng Bo
AU - Yang, Zhi Yong
AU - Huang, Xiao Qi
AU - Wu, Qi Zhu
AU - Zhu, Hong Yan
AU - Yu, Xue Feng
AU - Quan, Hong
AU - Gong, Qi Yong
PY - 2011
DA - 2011/12/14
TI - Bimodal Fluorescence and Magnetic Resonance Imaging Using Water-Soluble Hexagonal NaYF4:Ce,Tb,Gd Nanocrystals
SP - 531217
VL - 2011
AB - The present study explored the feasibility of using hexagonal-phase NaYF4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26%), and decent MR T1 relaxivity (r1=2.87 mM−1 s−1). The NaYF4:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF4:Ce,Tb,Gd NCs also significantly increased T1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.
SN - 1687-4110
UR - https://doi.org/10.1155/2011/531217
DO - 10.1155/2011/531217
JF - Journal of Nanomaterials
PB - Hindawi Publishing Corporation
KW -
ER -