TY - JOUR A2 - Phuruangrat, Anukorn AU - Ren, Wen Ting AU - Liang, Liang Bo AU - Qi, Fei AU - Sun, Zheng Bo AU - Yang, Zhi Yong AU - Huang, Xiao Qi AU - Wu, Qi Zhu AU - Zhu, Hong Yan AU - Yu, Xue Feng AU - Quan, Hong AU - Gong, Qi Yong PY - 2011 DA - 2011/12/14 TI - Bimodal Fluorescence and Magnetic Resonance Imaging Using Water-Soluble Hexagonal NaYF4:Ce,Tb,Gd Nanocrystals SP - 531217 VL - 2011 AB - The present study explored the feasibility of using hexagonal-phase NaYF4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26%), and decent MR T1 relaxivity (r1=2.87 mM−1 s−1). The NaYF4:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF4:Ce,Tb,Gd NCs also significantly increased T1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging. SN - 1687-4110 UR - https://doi.org/10.1155/2011/531217 DO - 10.1155/2011/531217 JF - Journal of Nanomaterials PB - Hindawi Publishing Corporation KW - ER -