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Journal of Nanomaterials
Volume 2011, Article ID 851520, 5 pages
Research Article

Magnetically Directed Targeting Aggregation of Radiolabelled Ferrite Nanoparticles

1Department of Nuclear Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi 62247, Taiwan
2School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
3School of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4Department of Physics, National Taiwan University, Taipei 10617, Taiwan
5Department of Pharmacy, Buddhist Dalin Tzu Chi General Hospital, Chiayi 62247, Taiwan

Received 12 August 2010; Accepted 10 April 2011

Academic Editor: Rakesh Joshi

Copyright © 2011 Yuh-Feng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ferrite magnetic nanoparticles (Fe3O4 or iron (II,III) oxide; 15–25 nm of diameter) were developed. These magnetic nanoparticles are a potential vehicle for magnetically induced target aggregation in living animals. In this preliminary study, the radiochemical purity for the radiolabeled magnetic nanoparticles was examined, and the possibility of the magnetically induced targeting of the radio-nanoparticles was evaluated. Our results showed that radiolabeled ferrite nanoparticles can be used as magnetic targeting agents with high labeling efficiency and stability. These particles can be distributed within living animals via intravenous injection, and the biodistribution of the particles can be potentially controlled by external magnetism. These evaluations will be the groundwork for the future development of delivery techniques for radiopharmaceuticals through external magnetic control.