Figure 5: (a) Typical Raman spectrum of the pDNA/NP complexes. (b): Representative SERS spectrum of the pDNA/NP complexes conjugated PLGA NPs and decorated with silver nanoparticles (SNPs). It can be observed that the strong scattering peaks corresponding to pDNA and since the signal was mostly collected due to the SERS effect generated by the SNPs, it can be concluded that the DNA is present mostly on the surface of the PLGA NPs.