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SPIO preparation | SPIO coating | Cell line | Aim | REF |
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(1) Thermal decomposition | PEG-PLA, cRGD ligand, and doxorubicin | SLK | Ligand targeted drug delivery and MRI | [9] |
(2) Coprecipitation | LHRH; LH/CG | MDA-MB-435S | Ligand targeted drug delivery and MRI | [10] |
(3) Coprecipitation | Dextran/PVA; Cy5.5/Cy3.5 | Brain-derived endothelial cells; microglial cells | MDT and MRI | [11] |
(4) Coprecipitation | Poly(TMSMA-r-PEGMA) | LLC in mice | MRI | [12] |
(5) Coprecipitation | DMSA ligand, rhodamine B, and fluorescein diacetate maleimide | HeLa | Fluorescent and magnetic cell labeling | [13] |
(6) Thermal cross-linking | Poly(3-(trimethoxysilyl)propyl methacrylate-r-PEG methyl ether, methacrylate-r-N-acryloxysuccinimide), and Cy5.5 | LLC | Dual-imaging probe | [14] |
(7) SPIONs purchased from (model Resovist, Schering AG, Germany) | Hydrogel | CT-26 mice cancer cells | Hyperthermia cancer therapy | [15] |
(8) SPIONs purchased from (SHU 555 A, Resovist; Schering, Berlin, Germany) | Carboxy dextran | CCL185 | R2 and R2* mapping | [16] |
(9) Thermal decomposition | Poly(amidoamine) dendrimers, 6-TAMRA fluorescent dye, and folic acid molecules | KB, UM-SCC-38 | MRI | [17] |
(10) Thermal cross-linking | Doxorubicin | LLC cells | MDT and MRI | [18] |
(11) Coprecipitation | Amine-functionalized PEG silane, Alexa Fluor 680 (AF680) fluorochrome, and CTX | C6 | Ligand targeted drug delivery | [19] |
(12) Coprecipitation | Glycerol monooleate, antibody HER2, paclitaxel, and rapamycin | MCF7 | Ligand targeted drug delivery | [20] |
(13) Coprecipitation | PEG, CTX, and Cy5.5 | Mouse bearing 9L gliosarcoma cells | Ligand targeted drug delivery and MRI | [21] |
(14) Cross-linking | Dextran, cRGD, epichlorohydrin, ammonia, and Cy5.5 | BT-20 tumor cells | Ligand targeted drug delivery and MRI | [22] |
(15) Cross-linking | Dextran, bombesin, epichlorohydrin, ammonia, and Cy5.5 | MIA-PaCa 2 | MRI | [23] |
(16) Coprecipitation | Paclitaxel | OECM1 | MDT | [24] |
(17) Coprecipitation | Oleic acid, pluronic, doxorubicin, and paclitaxel | MCF-7 breast cancer cells | MDT and MRI | [25] |
(18) Coprecipitation | 3-aminopropyltrimethoxysilane (APTMS), Arg-Gly-Asp, and (RGD) peptides | HaCaTras-A-5RT3, A431 tumors | Ligand targeted drug delivery and MRI | [26] |
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