Review Article

Superparamagnetic Nanoparticles and RNAi-Mediated Gene Silencing: Evolving Class of Cancer Diagnostics and Therapeutics

Table 1

SPIO-based formulation used for cancer therapy.

SPIO preparationSPIO coatingCell lineAimREF

(1) Thermal decompositionPEG-PLA, cRGD ligand, and doxorubicinSLKLigand targeted drug delivery and MRI[9]
(2) CoprecipitationLHRH; LH/CGMDA-MB-435SLigand targeted drug delivery and MRI[10]
(3) CoprecipitationDextran/PVA; Cy5.5/Cy3.5Brain-derived endothelial cells; microglial cellsMDT and MRI[11]
(4) CoprecipitationPoly(TMSMA-r-PEGMA)LLC in miceMRI[12]
(5) CoprecipitationDMSA ligand, rhodamine B, and fluorescein diacetate maleimideHeLaFluorescent and magnetic cell labeling[13]
(6) Thermal cross-linkingPoly(3-(trimethoxysilyl)propyl methacrylate-r-PEG methyl ether, methacrylate-r-N-acryloxysuccinimide), and Cy5.5LLCDual-imaging probe[14]
(7) SPIONs purchased from (model Resovist, Schering AG, Germany)HydrogelCT-26 mice cancer cellsHyperthermia cancer therapy[15]
(8) SPIONs purchased from (SHU 555 A, Resovist; Schering, Berlin, Germany)Carboxy dextranCCL185R2 and R2* mapping[16]
(9) Thermal decompositionPoly(amidoamine) dendrimers, 6-TAMRA fluorescent dye, and folic acid moleculesKB, UM-SCC-38MRI[17]
(10) Thermal cross-linkingDoxorubicinLLC cellsMDT and MRI[18]
(11) CoprecipitationAmine-functionalized PEG silane, Alexa Fluor 680 (AF680) fluorochrome, and CTXC6Ligand targeted drug delivery[19]
(12) CoprecipitationGlycerol monooleate, antibody HER2, paclitaxel, and rapamycinMCF7Ligand targeted drug delivery[20]
(13) CoprecipitationPEG, CTX, and Cy5.5Mouse bearing 9L gliosarcoma cellsLigand targeted drug delivery and MRI[21]
(14) Cross-linkingDextran, cRGD, epichlorohydrin, ammonia, and Cy5.5BT-20 tumor cellsLigand targeted drug delivery and MRI[22]
(15) Cross-linkingDextran, bombesin, epichlorohydrin, ammonia, and Cy5.5MIA-PaCa 2MRI[23]
(16) CoprecipitationPaclitaxelOECM1MDT[24]
(17) CoprecipitationOleic acid, pluronic, doxorubicin, and paclitaxelMCF-7 breast cancer cellsMDT and MRI[25]
(18) Coprecipitation3-aminopropyltrimethoxysilane (APTMS), Arg-Gly-Asp, and (RGD) peptidesHaCaTras-A-5RT3, A431 tumorsLigand targeted drug delivery and MRI[26]