Table of Contents Author Guidelines Submit a Manuscript
Journal of Nanomaterials
Volume 2012, Article ID 313961, 10 pages
http://dx.doi.org/10.1155/2012/313961
Research Article

5-Fluorouracil Encapsulated Chitosan Nanoparticles for pH-Stimulated Drug Delivery: Evaluation of Controlled Release Kinetics

1Biomedical Engineering Department, Zonguldak Karaelmas University, 67100 Zonguldak, Turkey
2Chemistry Department, Gazi University, Beşevler, 06500 Ankara, Turkey

Received 9 December 2011; Accepted 30 March 2012

Academic Editor: Jinquan Wei

Copyright © 2012 R. Seda Tığlı Aydın and Mehlika Pulat. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Feng, “Nanoparticles of biodegradable polymers for new-concept chemotherapy,” Expert Review of Medical Devices, vol. 1, no. 1, pp. 115–125, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Brannon-Peppas and J. O. Blanchette, “Nanoparticle and targeted systems for cancer therapy,” Advanced Drug Delivery Reviews, vol. 56, no. 11, pp. 1649–1659, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Devalapally, A. Chakilam, and M. M. Amiji, “Role of nanotechnology in pharmaceutical product development,” Journal of Pharmaceutical Sciences, vol. 96, no. 10, pp. 2547–2565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. W. Paul and C. P. Sharma, “Chitosan, a drug carrier for the 21st century: a review,” S.T.P. Pharma Sciences, vol. 10, no. 1, pp. 5–22, 2000. View at Google Scholar · View at Scopus
  5. J. M. Dang and K. W. Leong, “Natural polymers for gene delivery and tissue engineering,” Advanced Drug Delivery Reviews, vol. 58, no. 4, pp. 487–499, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. K. A. Janes, P. Calvo, and M. J. Alonso, “Polysaccharide colloidal particles as delivery systems for macromolecules,” Advanced Drug Delivery Reviews, vol. 47, no. 1, pp. 83–97, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Calvo, C. Remuñan-López, J. L. Vila-Jato, and M. J. Alonso, “Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines,” Pharmaceutical Research, vol. 14, no. 10, pp. 1431–1436, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. H. C. Yang and M. H. Hon, “The effect of the molecular weight of chitosan nanoparticles and its application on drug delivery,” Microchemical Journal, vol. 92, no. 1, pp. 87–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. K. A. Janes, M. P. Fresneau, A. Marazuela, A. Fabra, and M. J. Alonso, “Chitosan nanoparticles as delivery systems for doxorubicin,” Journal of Controlled Release, vol. 73, no. 2-3, pp. 255–267, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. Q. Gan and T. Wang, “Chitosan nanoparticle as protein delivery carrier-Systematic examination of fabrication conditions for efficient loading and release,” Colloids and Surfaces B, vol. 59, no. 1, pp. 24–34, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. L. Zhang, R. S. Srivastava, and R. D. K. Misra, “Core-shell magnetite nanoparticles surface encapsulated with smart stimuli-responsive polymer: synthesis, characterization, and LCST of viable drug-targeting delivery system,” Langmuir, vol. 23, no. 11, pp. 6342–6351, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Cha, W. B. Lee, C. R. Park, Y. W. Cho, C. H. Ahn, and I. C. Kwon, “Preparation and characterization of cisplatin-incorporated chitosan hydrogels, microparticles, and nanoparticles,” Macromolecular Research, vol. 14, no. 5, pp. 573–578, 2006. View at Google Scholar · View at Scopus
  13. T. López-León, E. L. S. Carvalho, B. Seijo, J. L. Ortega-Vinuesa, and D. Bastos-González, “Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior,” Journal of Colloid and Interface Science, vol. 283, no. 2, pp. 344–351, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Shah, W. MacDonald, and J. Goldie, “5-FU infusion in advanced colorectal cancer: a comparison of three dose schedules,” Cancer Treatment Reports, vol. 69, no. 7-8, pp. 739–742, 1985. View at Google Scholar · View at Scopus
  15. G. A. Caballero, R. K. Ausma, and E. J. Quebbema, “Long-term, ambulatory, continuous infusion of 5-FU for the treatment of advanced adenocarcinoma,” Cancer Treatment Reviews, vol. 69, pp. 13–16, 1985. View at Google Scholar
  16. N. Rapoport, “Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery,” Progress in Polymer Science, vol. 32, no. 8-9, pp. 962–990, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. E. K. Lim, Y. M. Huh, J. Yang, K. Lee, J. S. Suh, and S. Haam, “PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI,” Advanced Materials, vol. 23, no. 21, pp. 2436–2442, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. T. P. Hadjiioannou, G. D. Christian, M. A. Koupparis, and P. E. Macheras, Quantitative Calculations in Pharmaceutical Practice and Research, VCH Publishers, New York, NY, USA, 1993.
  19. D. W. A. Bourne, “Pharmacokinetics,” in Modern Pharmaceutics, G. S. Banker and C. T. Rhodes , Eds., pp. 67–93, Marcel Dekker, New York, NY, USA, 2002. View at Google Scholar
  20. T. Higuchi, “Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices,” Journal of Pharmaceutical Sciences, vol. 52, pp. 1145–1149, 1963. View at Google Scholar · View at Scopus
  21. A. W. Hixson and J. H. Crowell, “Dependence of reaction velocity upon surface and agitation,” Industrial & Engineering Chemistry, vol. 23, pp. 923–931, 1931. View at Google Scholar
  22. R. W. Korsmeyer, R. Gurny, and E. Doelker, “Mechanisms of solute release from porous hydrophilic polymers,” International Journal of Pharmaceutics, vol. 15, no. 1, pp. 25–35, 1983. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Kopcha, N. G. Lordi, and K. J. Tojo, “Evaluation of release from selected thermosoftening vehicles,” Journal of Pharmacy and Pharmacology, vol. 43, no. 6, pp. 382–387, 1991. View at Google Scholar · View at Scopus
  24. Q. Gan, T. Wang, C. Cochrane, and P. McCarron, “Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery,” Colloids and Surfaces B, vol. 44, no. 2-3, pp. 65–73, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Qi, Z. Xu, X. Jiang, C. Hu, and X. Zou, “Preparation and antibacterial activity of chitosan nanoparticles,” Carbohydrate Research, vol. 339, no. 16, pp. 2693–2700, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. De Campos, A. Sánchez, and M. J. Alonso, “Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A,” International Journal of Pharmaceutics, vol. 224, no. 1-2, pp. 159–168, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. F. L. Mi, S. S. Shyu, C. Y. Kuan, S. T. Lee, K. T. Lu, and S. F. Jang, “Chitosan-Polyelectrolyte complexation for the preparation of gel beads and controlled release of anticancer drug: I: effect of phosphorous polyelectrolyte complex and enzymatic hydrolysis of polymer,” Journal of Applied Polymer Science, vol. 74, pp. 1868–1879, 1999. View at Google Scholar
  28. J. Zhao and J. Wu, “Preparation and characterization of the fluorescent chitosan nanoparticle probe,” Chinese Journal of Analytical Chemistry, vol. 34, no. 11, pp. 1555–1559, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Katas and H. O. Alpar, “Development and characterisation of chitosan nanoparticles for siRNA delivery,” Journal of Controlled Release, vol. 115, no. 2, pp. 216–225, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Csaba, M. Köping-Höggård, and M. J. Alonso, “Ionically crosslinked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery,” International Journal of Pharmaceutics, vol. 382, no. 1-2, pp. 205–214, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Kondo and M. Araie, “Iontophoresis of 5-fluorouracil into the conjunctiva and sclera,” Investigative Ophthalmology and Visual Science, vol. 30, no. 3, pp. 583–585, 1989. View at Google Scholar · View at Scopus
  32. C. Gonçalves, P. Pereira, and M. Gama, “Self-assembled hydrogel nanoparticles for drug delivery applications,” Materials, vol. 3, pp. 1420–1460, 2010. View at Google Scholar
  33. M. Hamidi, A. Azadi, and P. Rafiei, “Hydrogel nanoparticles in drug delivery,” Advanced Drug Delivery Reviews, vol. 60, no. 15, pp. 1638–1649, 2008. View at Publisher · View at Google Scholar · View at Scopus